{"data":{"id":"us/21-cfr-170.22","jurisdiction":"us","citation":"21 CFR 170.22","heading":"Safety factors to be considered.","body":"In accordance with section 409(c)(5)(C) of the Act, the following safety factors will be applied in determining whether the proposed use of a food additive will be safe: Except where evidence is submitted which justifies use of a different safety factor, a safety factor in applying animal experimentation data to man of 100 to 1, will be used; that is, a food additive for use by man will not be granted a tolerance that will exceed 1/100th of the maximum amount demonstrated to be without harm to experimental animals.","path":["Title 21—Food and Drugs","CHAPTER I—FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES","SUBCHAPTER B—FOOD FOR HUMAN CONSUMPTION","PART 170—FOOD ADDITIVES","Subpart B—Food Additive Safety"],"source_url":"https://www.ecfr.gov/api/versioner/v1/full/2026-08-25/title-21.xml","current_through":"2026-08-25","vintage":"","retrieved_at":"2026-08-27T02:24:47Z","sha256":"cfef711b876a884e0d864aa6bb2a63f8a1f039c2cc5069aaea1fd6a3252a8fff","source_id":"us-cfr","stale":true,"prev":"us/21-cfr-170.20","next":"us/21-cfr-170.30"},"notice":"GroundRules: Original legal text. Not legal advice."}