{"data":{"id":"us/21-cfr-170.280","jurisdiction":"us","citation":"21 CFR 170.280","heading":"Submission of a supplement.","body":"If circumstances warrant, you may submit a supplement to a filed GRAS notice after we respond to your notice by letter in accordance with § 170.265(b)(1) or cease to evaluate your notice in accordance with § 170.265(b)(3).","path":["Title 21—Food and Drugs","CHAPTER I—FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES","SUBCHAPTER B—FOOD FOR HUMAN CONSUMPTION","PART 170—FOOD ADDITIVES","Subpart E—Generally Recognized as Safe (GRAS) Notice"],"source_url":"https://www.ecfr.gov/api/versioner/v1/full/2026-08-25/title-21.xml","current_through":"2026-08-25","vintage":"","retrieved_at":"2026-08-27T02:24:47Z","sha256":"c71baf15be027e5fa65d1a2da74937e5e91154b564eaaafcbdac99a9aecaed4f","source_id":"us-cfr","stale":true,"prev":"us/21-cfr-170.275","next":"us/21-cfr-170.285"},"notice":"GroundRules: Original legal text. Not legal advice."}