{"data":{"id":"us/21-cfr-346.18","jurisdiction":"us","citation":"21 CFR 346.18","heading":"Astringent active ingredients.","body":"The active ingredient of the product consists of any of the following when used within the concentration range established for each ingredient:\n(a) Calamine, within a concentration range of 5 to 25 percent by weight per dosage unit (based on the zinc oxide content of calamine).\n(b) Witch hazel, 10 to 50 percent.\n(c) Zinc oxide, within a concentration range of 5 to 25 percent by weight per dosage unit.","path":["Title 21—Food and Drugs","CHAPTER I—FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES","SUBCHAPTER D—DRUGS FOR HUMAN USE","PART 346—ANORECTAL DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE","Subpart B—Active Ingredients"],"source_url":"https://www.ecfr.gov/api/versioner/v1/full/2026-08-25/title-21.xml","current_through":"2026-08-25","vintage":"","retrieved_at":"2026-08-27T02:24:47Z","sha256":"58cd87f5bdfcf9f2633ab14cd4a59a38e046b5199e89e44e73dfa06eb526bce8","source_id":"us-cfr","stale":true,"prev":"us/21-cfr-346.16","next":"us/21-cfr-346.20"},"notice":"GroundRules: Original legal text. Not legal advice."}