{"data":{"id":"us/21-cfr-349.30","jurisdiction":"us","citation":"21 CFR 349.30","heading":"Permitted combinations of active ingredients.","body":"The following combinations are permitted provided each active ingredient is present within the established concentration, and the product is labeled in accordance with § 349.79.\n(a) Any single ophthalmic astringent active ingredient identified in § 349.10 may be combined with any single ophthalmic vasoconstrictor active ingredient identified in § 349.18.\n(b) Any two or three ophthalmic demulcent active ingredients identified in § 349.12 may be combined.\n(c) Any single ophthalmic demulcent active ingredient identified in § 349.12 or any ophthalmic demulcent combination identified in paragraph (b) of this section may be combined with any single ophthalmic vasoconstrictor identified in § 349.18.\n(d) Any single ophthalmic astringent active ingredient identified in § 349.10 may be combined with any single ophthalmic vasoconstrictor active ingredient identified in § 349.18 and any single ophthalmic demulcent identified in § 349.12 or ophthalmic demulcent combination identified in paragraph (b) of this section.\n(e) Any two or more emollient active ingredients identified in § 349.14 may be combined as necessary to give the product proper consistency for application to the eye.","path":["Title 21—Food and Drugs","CHAPTER I—FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES","SUBCHAPTER D—DRUGS FOR HUMAN USE","PART 349—OPHTHALMIC DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE","Subpart B—Active Ingredients"],"source_url":"https://www.ecfr.gov/api/versioner/v1/full/2026-08-25/title-21.xml","current_through":"2026-08-25","vintage":"","retrieved_at":"2026-08-27T02:24:47Z","sha256":"684cacf1b0e9423e0bac752dff1fdd3611d0a6bc82eab19cfa53d8ff15651288","source_id":"us-cfr","stale":true,"prev":"us/21-cfr-349.20","next":"us/21-cfr-349.50"},"notice":"GroundRules: Original legal text. Not legal advice."}