{"data":{"id":"us/21-cfr-570.245","jurisdiction":"us","citation":"21 CFR 570.245","heading":"Part 5 of a GRAS notice: Experience based on common use in food before 1958.","body":"If the statutory basis for your conclusion of GRAS status is through experience based on common use in animal food, in Part 5 of your GRAS notice you must include evidence of a substantial history of consumption of the notified substance for food use by a significant number of animals of the species to which the substance is intended to be fed prior to January 1, 1958, and evidence of a substantial history of consumption by humans consuming human foods derived from food-producing animals prior to January 1, 1958.","path":["Title 21—Food and Drugs","CHAPTER I—FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES","SUBCHAPTER E—ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS","PART 570—FOOD ADDITIVES","Subpart E—Generally Recognized as Safe (GRAS) Notice"],"source_url":"https://www.ecfr.gov/api/versioner/v1/full/2026-08-25/title-21.xml","current_through":"2026-08-25","vintage":"","retrieved_at":"2026-08-27T02:24:47Z","sha256":"062c9df786d26ca701d94208b1c03cf7374973ca090bd02f3a884092dd83a0c9","source_id":"us-cfr","stale":true,"prev":"us/21-cfr-570.240","next":"us/21-cfr-570.250"},"notice":"GroundRules: Original legal text. Not legal advice."}