{"data":{"id":"us/21-cfr-70.40","jurisdiction":"us","citation":"21 CFR 70.40","heading":"Safety factors to be considered.","body":"In accordance with section 721(b)(5)(A)(iii) of the act, the following safety factor will be applied in determining whether the proposed use of a color additive will be safe: Except where evidence is submitted which justifies use of a different safety factor, a safety factor of 100 to 1 will be used in applying animal experimentation data to man; that is, a color additive for use by man will not be granted a tolerance that will exceed 1/100th of the maximum no-effect level for the most susceptible experimental animals tested. The various species of experimental animals used in the tests shall conform to good pharmacological practice.","path":["Title 21—Food and Drugs","CHAPTER I—FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES","SUBCHAPTER A—GENERAL","PART 70—COLOR ADDITIVES","Subpart C—Safety Evaluation"],"source_url":"https://www.ecfr.gov/api/versioner/v1/full/2026-08-25/title-21.xml","current_through":"2026-08-25","vintage":"","retrieved_at":"2026-08-27T02:24:47Z","sha256":"0952493c3e4fcfefb0bfda3f904ad8ede2db70146a328f54a2bf94d731837b89","source_id":"us-cfr","stale":true,"prev":"us/21-cfr-70.25","next":"us/21-cfr-70.42"},"notice":"GroundRules: Original legal text. Not legal advice."}